GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7849270 | 1 | rs7036236 | chr9:131899299 | CRAT | chr9:131857075-131873070:- | 0.29 | 7.06 | 5.88E-12 | Blood metabolite ratios |
| THCA | cis | rs881375 | 1 | rs7037140 | chr9:123656327 | LOC253039 | chr9:123605320-123616644:+ | -0.5 | -9.11 | 2.3E-18 | Rheumatoid arthritis |
| THCA | cis | rs881375 | 1 | rs7037140 | chr9:123656327 | PSMD5 | chr9:123578334-123605206:- | -0.27 | -5.21 | 2.76E-7 | Rheumatoid arthritis |
| THCA | cis | rs7849270 | 1 | rs7037163 | chr9:131894340 | CRAT | chr9:131857075-131873070:- | 0.28 | 6.64 | 8.68E-11 | Blood metabolite ratios |
| THCA | cis | rs703842 | 1 | rs703842 | chr12:58162739 | FAM119B | chr12:58166383-58176323:+ | -0.39 | -11.02 | 2.53E-25 | Multiple sclerosis |
| THCA | cis | rs703842 | 1 | rs703842 | chr12:58162739 | METTL1 | chr12:58162352-58165914:- | 0.17 | 4.12 | 4.51E-5 | Multiple sclerosis |
| THCA | cis | rs703842 | 1 | rs703842 | chr12:58162739 | TSFM | chr12:58176536-58191367:+ | 0.53 | 17.89 | 3.72E-55 | Multiple sclerosis |
| THCA | cis | rs703842 | 1 | rs703842 | chr12:58162739 | XRCC6BP1 | chr12:58335445-58351051:+ | 0.22 | 4.55 | 6.78E-6 | Multiple sclerosis |
| THCA | cis | rs10760706 | 1 | rs7038506 | chr9:102710132 | STX17 | chr9:102668915-102736817:+ | -0.16 | -4.17 | 3.68E-5 | Alopecia areata |
| THCA | cis | rs6477998 | 1 | rs7038769 | chr9:116007583 | CDC26 | chr9:116029290-116037869:- | -0.47 | -10.6 | 1.04E-23 | Hematology traits |
| THCA | cis | rs6477998 | 1 | rs7038769 | chr9:116007583 | PRPF4 | chr9:116037974-116055054:+ | 0.18 | 4.3 | 2.1E-5 | Hematology traits |
| THCA | cis | rs10760706 | 1 | rs7039716 | chr9:102670215 | STX17 | chr9:102668915-102736817:+ | -0.16 | -4.19 | 3.39E-5 | Alopecia areata |
| THCA | cis | rs704 | 1 | rs704 | chr17:26694861 | TMEM97 | chr17:26646121-26655710:+ | 0.3 | 6.27 | 8.06E-10 | Osteoprotegerin levels |
| THCA | cis | rs7027110 | 1 | rs7044116 | chr9:109595771 | ZNF462 | chr9:109625378-109773789:+ | -0.11 | -3.86 | 0.000132 | Height |
| THCA | cis | rs7045138 | 1 | rs7045138 | chr9:100591463 | C9orf156 | chr9:100666772-100684852:- | 0.17 | 4.69 | 3.54E-6 | Thyroid hormone levels |